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| Corina Wirth |
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medicine
- Neuroscience, science policy |
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Publicationsshow all | article | book | citation |
2004 | 2003 |
| Development of 3-D Multi-Electrode Arrays for Use with Acute Tissue Slices | | | Marc Olivier Heuschkel, Corina Wirth, Esther-Marie Steidl, Bruno Buisson | | |
Advances in Network Electrophysiology Using Multi-Electrode Arrays. M. Taketani, M. Baudry, Springer Verlag, 2006 | | |
Abstract: Multi-site recording of neuronal activity in freshly prepared slices provides an ideal approach towards understanding the function of neuronal processing in complex networks. Such an approach has given elegant results with native retina where ganglionic neurons could be recorded by planar Multi-Electrode Arrays (MEA). Other brain regions display some 2-D-organized networks, but these structures need to be sectioned prior to use with multi-electrode arrays. Some of these preparations (hippocampus, cerebellum, cortex, and spinal cord) have been used for many years with conventional glass electrodes that could be placed directly on active living cells. The dead cell layer of mechanically cut slices constitutes, however, an insulation layer between living neurons and the electrodes of planar arrays, preventing the achievement of a good signal-to-noise ratio. The recent development of 3-D tip-shaped electrode arrays now offers the technical opportunity to record from acute slices with unprecedented spatiotemporal resolution. This book chapter gives an overview of the most recent technical developpement and experimental application of MEA. | | |
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